Wayne Research Group
Journal Articles
Capturing the Dynamics of STAT6 Macrophage Polarization Using Bioluminescence Temporal Spectrometry
Zheng S, Chiang Y, Aldarondo D, Fox Z.R., Akpa B.S., and Wayne E.C.# Capturing the Dynamics of STAT6 Macrophage Polarization Using Bioluminescence Temporal Spectrometry. Accepted at Cell Systems. Pre-print: http://dx.doi.org/10.2139/ssrn.468225
Quantitative Analysis of Monocyte-Derived Macrophage NFκB Signaling in Cancer Co-culture Models Using Luciferase-Based Biosensing
Li C., Anand M., McPheron G., ..., and Wayne E.C. # Quantitative Analysis of Monocyte-Derived Macrophage NFκB Signaling in Cancer Co-culture Models Using Luciferase-Based Biosensing. Cel. Mol. Bioeng. 18, 419–432 (2025). https://doi.org/10.1007/s12195-025-00870-1. CMBE Young Innovator Special Issue.
Bioprinted platform for parallelized screening of engineered microtissues in vivo
O'Connor C.E., Zhang F., Neufeld A., Prado O., Simmonds S.P., Fortin C.L., Johansson F., Mene J., Saxton S.H., Kopyeva I., Gregorio N.E., James Z., DeForest C.A., Wayne E.C. #, Witten D.M., Stevens K.R. Bioprinted platform for parallelized screening of engineered microtissues in vivo. Cell Stem Cell. 2025 May 1;32(5):838-853.e6. doi:10.1016/j.stem.2025.03.002. PMID: 40168987; PMCID: PMC12107472.
Exploratory mapping of tumor-associated macrophage nanoparticle article abstracts using an eLDA topic modeling machine learning approach
Brown C., Bilynsky C.S.M., Gainey M., Young S., Kitchin J., and Wayne E.C. # (2024). Exploratory mapping of tumor-associated macrophage nanoparticle article abstracts using an eLDA topic modeling machine learning approach. PLOS ONE 19(6): e0304505. https://doi.org/10.1371/journal.pone.0304505
Moving from Talk to Action: Building an Accountability Plan to Diversify Engineering
Linnes J., Moore E., Porras A.M., Wayne E.C., Boyle P., Chow L., Maisel K., Peyton S., Stabenfelt S., Stevens K., Jergens E., and Willits R. Moving from Talk to Action: Building an Accountability Plan to Diversify Engineering. Nature Reviews Bioengineering 2, 521–530 (2024). https://doi.org/10.1038/s44222-024-00183-4
Measuring and Modeling Macrophage Growth Using a Lab-on-CMOS Capacitance Sensing Microsystem
Smith K., Lin C.Y., Gilpin Y., Wayne E.C.* # and Dandin M.* # Measuring and Modeling Macrophage Growth Using a Lab-on-CMOS Capacitance Sensing Microsystem. Accepted, Frontiers in Bioengineering and Biotechnology. *Equal contribution.
Monocytes as a Convergent Nanoparticle Therapeutic Target for Cardiovascular Diseases
Aldarondo D.A. and Wayne E.C.#Monocytes as a Convergent Nanoparticle Therapeutic Target for Cardiovascular Diseases. Advanced Drug Delivery Reviews(2022). 182. https://doi.org/10.1016/j.addr.2022.114116
Ancestry of cells must be considered in bioengineering
Moore E., Allen J.B., Mulligan C.J., and Wayne E.C. Ancestry of cells must be considered in bioengineering. Nat Reviews Materials (2022). https://doi.org/10.1038/s41578-021-00397-7
Rapid growth in the COVID-19 era
Lee Y., Ng M., Daniel K., and Wayne E.C. # Rapid growth in the COVID-19 era. MRS Bulletin 46, 847–853 (2021). https://doi.org/10.1557/s43577-021-00185-2
Preparation and Characterization of Poly(2-oxazoline) Micelles for the Solubilization and Delivery of Water-Insoluble Drugs
Vinod N., Hwang D., Azam S.H., Swearingen A.E.D.V., Wayne E.C., Fussell S.C., Sokolsky-Papkov M., Pecot C.V., Kabanov A.V. Preparation and Characterization of Poly(2-oxazoline) Micelles for the Solubilization and Delivery of Water-Insoluble Drugs. Bio-protocol 11(6):e3959 (2021).
Preparation of an Orthotopic, Syngeneic Model of Lung Adenocarcinoma and the Testing of the Antitumor Efficacy of Poly(2-oxazoline) Formulation of Chemo- and Immunotherapeutic Agents
Vinod N., Hwang D., Azam S.H., Swearingen A.E.D.V., Wayne E.C., Fussell S.C., Sokolsky-Papkov M., Pecot C.V., Kabanov A.V. Preparation of an Orthotopic, Syngeneic Model of Lung Adenocarcinoma and the Testing of the Antitumor Efficacy of Poly(2-oxazoline) Formulation of Chemo- and Immunotherapeutic Agents. Bio-protocol 11(6):e3953 (2021). doi:10.21769/BioProtoc.3953.
The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Autoimmune Disorders
Lu M., DiBernardo E., Parks E., Fox H., Zheng S., Wayne E.C. # The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Autoimmune Disorders. Frontiers in Immunology., 24 February 2021. 12. https://www.frontiersin.org/article/10.3389/fimmu.2021.566299
High-Capacity Poly(2-Oxazoline) Formulation of TLR 7/8 Agonist Extends Survival in a Chemo-Insensitive, Metastatic Model of Lung Adenocarcinoma
Vinod N., Hwang D., Azam S.H., Swearingen A.E.D.V., Wayne E.C., Fussell S.C., Sokolsky-Papkov M., Pecot C.V., Kabanov A.V. High-Capacity Poly(2-Oxazoline) Formulation of TLR 7/8 Agonist Extends Survival in a Chemo-Insensitive, Metastatic Model of Lung Adenocarcinoma. Science Advances. 6(25), 2020.
Targeted Delivery of siRNA Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer
Wayne E.C., Long C., Haney M.J., Batrakova E.V., Leisner T.M., Parise L.V., Kabanov A.V. Targeted Delivery of siRNA Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer. Advanced Science 6(21), 1900582 (2019). https://doi.org/10.1002/advs.201900582. 2019 Top 10% Most-downloaded article from Advanced Science.
A giant leap for womankind
Valantine H., Travis E., El-Adhami W., Vernos I., Mosqueda L., Wayne E.C., et al. A giant leap for womankind. Nature Medicine 25, 704–707 (2019). https://doi.org/10.1038/s41591-019-0446-y
Exploitation of P-glycoprotein Agonists to Retain Nanoparticles in the Brain Capillaries
Crawford L.A., Watkins H.C., Wayne E.C., Putnam D. Exploitation of P-glycoprotein Agonists to Retain Nanoparticles in the Brain Capillaries. Regenerative Engineering and Translational Medicine (2019). https://doi.org/10.1007/s40883-019-00111-8
TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer
Wayne E.C., Chandrasekaran S., Mitchell M.J., Chan M.F., Lee R.E., Schaffer C.B., King M.R. (2016). TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer. Journal of Controlled Release, 223, 215–223. http://doi.org/10.1016/j.jconrel.2015.12.048.
TRAIL-Coated Leukocytes That Kill Cancer Cells in the Circulation
Mitchell M.J., Wayne E.C.,Rana K., Schaffer C.B., King M.R. (2014). TRAIL-Coated Leukocytes That Kill Cancer Cells in the Circulation. Proceedings of the National Academy of Sciences 111(3), 930–935. https://doi.org/10.1073/pnas.1316312111
Mechanistic Insight into the TH1-Biased Immune Response to Recombinant Subunit Vaccines Delivered by Probiotic Bacteria-Derived Outer Membrane Vesicles
Rosenthal J.A., Huang C.-J., Doody A.M., Leung T., Mineta K., Feng D., Wayne E.C., Nishimura N., Leifer C., DeLisa M.P., Mendez S., Putnam D. (2014). Mechanistic Insight into the TH1-Biased Immune Response to Recombinant Subunit Vaccines Delivered by Probiotic Bacteria-Derived Outer Membrane Vesicles. PLoS ONE 9(11): e112802. https://doi.org/10.1371/journal.pone.0112802